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Invitrogen™ TC2N Polyclonal Antibody
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Catalog No. PIPA532086
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100 μL
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PIPA532086 100 μL
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Catalog No. PIPA532086 Supplier Invitrogen™ Supplier No. PA532086
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549. Predicted reactivity: Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The TC2N gene encodes the Tandem C2 domains nuclear protein, which is characterized by the presence of two C2 domains, C2A and C2B, at the C-terminus. These domains are structured as an eight-stranded antiparallel beta-sandwich, initially recognized as a Ca2+ binding module. TC2N's role varies significantly across different types of cancer. It has been identified as an oncogene in lung, gastric, and hepatocellular carcinomas, where its overexpression promotes cell proliferation, migration, and metastasis. Conversely, in breast cancer, TC2N functions as a tumor suppressor, inhibiting distant metastasis and stemness via the PI3K-Akt signaling pathway. These dual roles highlight its complex involvement in tumorigenesis, with its impact being highly context-dependent on the cancer type.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TC2N
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene TC2N
Gene Accession No. Q8N9U0
Gene Alias 4933406D09Rik; C14orf47; C2 calcium-dependent domain containing 1; C2CD1; membrane targeting (tandem) C2 domain containing 1; membrane targeting tandem C2 domain-containing protein 1; MTAC2D1; Tac2-N; Tandem C2 domains nuclear protein; tandem C2 domains, nuclear; tandem C2 protein in nucleus; TC2N
Gene Symbols TC2N
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human TC2N. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 123036
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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