Invitrogen™ TC2N Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555651

Catalog No. PIPA555651

Description

Immunogen sequence: IKSCCGGCFY GETEKHNFSV ERDFKAAVPN SQNATISVPP LTSVSVKPQL GCTEDYLLSK LPSDGKEVPF VVPKFKLSYI QPRTQETPSH LEELEGSARA SFGDRKVELS SSSQHGPSYD VYNPFYMYQH ISPDLSRRF Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 78%.

The TC2N gene encodes the Tandem C2 domains nuclear protein, which is characterized by the presence of two C2 domains, C2A and C2B, at the C-terminus. These domains are structured as an eight-stranded antiparallel beta-sandwich, initially recognized as a Ca2+ binding module. TC2N's role varies significantly across different types of cancer. It has been identified as an oncogene in lung, gastric, and hepatocellular carcinomas, where its overexpression promotes cell proliferation, migration, and metastasis. Conversely, in breast cancer, TC2N functions as a tumor suppressor, inhibiting distant metastasis and stemness via the PI3K-Akt signaling pathway. These dual roles highlight its complex involvement in tumorigenesis, with its impact being highly context-dependent on the cancer type.

Specifications

• Antigen: TC2N
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TC2N
• Gene Alias: 4933406D09Rik; C14orf47; C2 calcium-dependent domain containing 1; C2CD1; membrane targeting (tandem) C2 domain containing 1; membrane targeting tandem C2 domain-containing protein 1; MTAC2D1; Tac2-N; Tandem C2 domains nuclear protein; tandem C2 domains, nuclear; tandem C2 protein in nucleus; TC2N
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 123036
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry, Western Blot
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N9U0
• Gene Symbols: TC2N
• Immunogen: Recombinant protein corresponding to Human TC2N. Recombinant protein control fragment (Product #RP-88889).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov