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Invitrogen™ TCF2 Monoclonal Antibody (CL0374)
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Catalog No. PIMA524605
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100 μL
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Catalog No. Quantity
PIMA524605 100 μL
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Catalog No. PIMA524605 Supplier Invitrogen™ Supplier No. MA524605
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Description

Mouse Monoclonal Antibody

Immunogen sequence: KEVLVQALEE LLPSPNFGVK LETLPLSPGS GAEPDTKPVF HTLTNGHAKG RLSGDEGSED GDDYDTPPIL KELQALNTEE AAEQRAEVDR MLSEDPWRAA KMIKGYMQQH Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%. Binds to an epitope located within the peptide sequence TPPILKELQA as determined by overlapping synthetic peptides.

Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCF2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL0374
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HNF1B
Gene Accession No. P35680
Gene Alias FJHN; Hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor-1 beta; HNF1 beta A; HNF1 homeobox B; HNF1B; Hnf-1b; Hnf1beta; HNF-1Beta; HNF-1-beta; HNF2; homeoprotein LFB3; HPC11; LFB3; LF-B3; MODY5; Tcf2; Tcf-2; Transcription factor 2; Transcription factor 2 hepatic; Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor; transcription factor 2, hepatic; Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor; variant hepatic nuclear factor 1; vHNF1
Gene Symbols HNF1B
Host Species Mouse
Immunogen Recombinant protein fragment of Human HNF1B (Product #RP-100696)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6928
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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