Invitrogen™ TCF2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518642

Catalog No. PIPA518642

Description

This antibody is predicted to react with bovine, canine, mouse, porcine, rat and zebrafish based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: TCF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HNF1B
• Gene Alias: FJHN; Hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor-1 beta; HNF1 beta A; HNF1 homeobox B; HNF1B; Hnf-1b; Hnf1beta; HNF-1Beta; HNF-1-beta; HNF2; homeoprotein LFB3; HPC11; LFB3; LF-B3; MODY5; Tcf2; Tcf-2; Transcription factor 2; Transcription factor 2 hepatic; Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor; transcription factor 2, hepatic; Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor; variant hepatic nuclear factor 1; vHNF1
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 21410, 6928
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P27889, P35680
• Gene Symbols: HNF1B
• Immunogen: Synthetic peptide sequence (QAYDRQKNPSKEER) corresponding to the internal amino acids of HNF1B (aa 248-262).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG