Invitrogen™ TCF4/TCF12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536151

Catalog No. PIPA536151

Description

This antibody detects endogenous protein at a molecular weight of 60 and 72 kDa. Purity is >95% by SDS-PAGE.

T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group(HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to beta-catenin in a cooperative manner. This TCF-4/ beta-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.

Specifications

• Antigen: TCF4/TCF12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TCF4
• Gene Alias: 5730422P05Rik; A130037E08Rik; Alf1; ASP-I2; bHLHb19; bHLHb20; Class A helix-loop-helix transcription factor ME1; class A helix-loop-helix transcription factor ME2; Class B basic helix-loop-helix protein 19; class B basic helix-loop-helix protein 20; CRS3; DNA-binding protein HTF4; E2.2; E2-2; E-box-binding protein; FECD3; HEB; HEBAlt; helix-loop-helix transcription factor 4; HsT17266; HTF4; HTF-4; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF2; ITF-2; ITF-2b; ME1; ME2; Meb; MITF-2; MITF-2A; MITF-2B; PTHS; R8f DNA-binding protein; REB; RITF-2; salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBPA; SCBP-alpha; SEF2; SEF-2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; SL3-3 enhancer factor 2; TCF12; TCF-12; Tcf4; TCF-4; TFE; transcription factor 12; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R; transcription factor HTF-4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21406, 21413, 25720, 6925, 6938, 84382
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P15884, P51514, Q60722, Q61286, Q62655, Q99081
• Gene Symbols: TCF12, TCF4
• Immunogen: Synthetic peptide corresponding to amino acids 580-630 of human TCF-4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov