Invitrogen™ TCF7 Polyclonal Antibody

Catalog No.	Quantity
PIPA591923	100 μL

Catalog No. PIPA591923 Supplier Invitrogen™ Supplier No. PA591923

Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse spleen; Cellular Location: Nucleus Immunogen sequence: ELKSSLVNES EGAAGGAGIP GVPGAGAGAR GEAEALGREH AAQRLFPDKL PEPLEDGLKA PECTSGMYKE TVYSAFNLLM HYPPPSGAGQ HPQPQPPLHK A.

TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Specifications

• Antigen: TCF7
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.95 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene: TCF7
• Gene Accession No.: P36402, Q00417
• Gene Alias: AI465550; HMG-box; OTTHUMP00000159390; OTTHUMP00000159391; T cell factor-1; T-cell factor 1; T-cell specific; T-cell-specific transcription factor 1; Tcf1; TCF-1; Tcf7; TCF-7; Transcription factor 7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7, T cell specific; transcription factor 7, T-cell specific
• Gene Symbols: TCF7
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TCF1/TCF7 (NP_0031932).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21414, 363595, 6932
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG