Invitrogen™ TCF7L2 Monoclonal Antibody (T.473.8)

Catalog No.	Quantity
PIMA514935	100 μL

Catalog No. PIMA514935 Supplier Invitrogen™ Supplier No. MA514935

Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

Specifications

• Antigen: TCF7L2
• Applications: ChIP Assay, Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: T.473.8
• Concentration: 36 μg/mL
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 50% glycerol, 0.15M NaCl, 100μg/mL BSA and <0.02% sodium azide; pH 7.5
• Gene: Tcf7l2
• Gene Accession No.: Q9NQB0
• Gene Alias: HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; mTcf-4B; mTcf-4E; RP11-357H24.1; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant F; T-cell factor-4 variant G; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF 4; TCF4; TCF-4; TCF4B; TCF4E; Tcf7l2; TCF7L2 protein; transcription factor 7 like 2; transcription factor 7 like 2, T cell specific, HMG box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor Tcf4
• Gene Symbols: Tcf7l2
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues surrounding Leu331 of human TCF4.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6934
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG