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Invitrogen™ TCIRG1 Polyclonal Antibody
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Catalog No. PIPA590425
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100 μL
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PIPA590425 100 μL
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Catalog No. PIPA590425 Supplier Invitrogen™ Supplier No. PA590425
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRA QLHQLQLHAA; Positive Samples: U2OS, A-549, BxPC-3, U-937, HL-60, Mouse thymus, Mouse skeletal muscle, Rat thymus, Rat skeletal muscle; Cellular Location: Membrane, Multi-pass membrane protein.

The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCIRG1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene TCIRG1
Gene Accession No. Q13488
Gene Alias a3; ATP6a3; Atp6i; ATP6N1C; ATP6V0A3; ATPase, H+ transporting, 116kD; ATPase, H+ transporting, lysosomal I; ATPase, H+ transporting, lysosomal V0 protein a; oc; OC116; OC-116; OC-116 kDa; OC-116kDa; OPTB1; osteoclastic proton pump; osteoclastic proton pump 116 kDa subunit; osteosclerotic; specific 116-kDa vacuolar proton pump subunit; Stv1; T cell immune response cDNA7 protein; T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell immune regulator 1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3; T-cell immune response cDNA 7; T-cell immune response cDNA7 protein; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; TCIRG1; TIRC7; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3; V-ATPase 116 kDa isoform a3; V-ATPase 116-kDa; V-ATPase a3; v-H+ATPase subunit a3; Vph1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a isoform 3
Gene Symbols TCIRG1
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10312, 27060, 293650
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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