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Invitrogen™ TCL1A Polyclonal Antibody
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Catalog No. PIPA5102316
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100 μL
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PIPA5102316 100 μL
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Catalog No. PIPA5102316 Supplier Invitrogen™ Supplier No. PA5102316
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TCL1A.

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (summarized by Virgilio et al., 1998). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCL1A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TCL1A
Gene Accession No. P56279, P56280
Gene Alias oncogene TCL1; Oncogene TCL-1; Protein p14 TCL1; T cell lymphoma breakpoint 1; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein) (TCL1 oncogene) (TCL-1 protein); T-cell lymphoma breakpoint 1; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1; TCL-1; TCL1A
Gene Symbols Tcl1, TCL1A
Host Species Rabbit
Immunogen A synthesized peptide derived from human TCL1A(Accession P56279), corresponding to amino acid residues R60-L110.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21432, 690575, 8115
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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