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Invitrogen™ TCOF1 Polyclonal Antibody
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Catalog No. PIPA5101158
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100 μL
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PIPA5101158 100 μL
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Catalog No. PIPA5101158 Supplier Invitrogen™ Supplier No. PA5101158
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TCOF1.

Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCOF1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TCOF1
Gene Accession No. O08784, Q13428
Gene Alias AA408847; AW209012; MFD1; nucleolar trafficking phosphoprotein; Tcof1; TCS; TCS1; Treacher Collins Franceschetti syndrome 1, homolog; Treacher Collins syndrome protein; Treacher Collins syndrome protein homolog; Treacher Collins-Franceschetti syndrome 1; Treacher Collins-Franceschetti syndrome 1 homolog; treacle; Treacle protein; treacle ribosome biogenesis factor 1
Gene Symbols TCOF1
Host Species Rabbit
Immunogen A synthesized peptide derived from human TCOF1(Accession Q13428), corresponding to amino acid residues G35-S85.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21453, 6949
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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