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Invitrogen™ TCOF1 Polyclonal Antibody
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Catalog No. PIPA558308
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100 μL
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PIPA558308 100 μL
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Catalog No. PIPA558308 Supplier Invitrogen™ Supplier No. PA558308
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KSLGNILQAK PTSSPAKGPP QKAGPVAVQV KAEKPMDNSE SSEESSDSAD SEEAPAAMTA AQAKPALKIP QTKACPKKTN TTAS Highest antigen sequence identity to the following orthologs: Mouse - 44%, Rat - 52%.

Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCOF1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TCOF1
Gene Accession No. Q13428
Gene Alias AA408847; AW209012; MFD1; nucleolar trafficking phosphoprotein; Tcof1; TCS; TCS1; Treacher Collins Franceschetti syndrome 1, homolog; Treacher Collins syndrome protein; Treacher Collins syndrome protein homolog; Treacher Collins-Franceschetti syndrome 1; Treacher Collins-Franceschetti syndrome 1 homolog; treacle; Treacle protein; treacle ribosome biogenesis factor 1
Gene Symbols TCOF1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TCOF1. Recombinant protein control fragment (Product #RP-96815).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6949
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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