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Invitrogen™ TCOF1 Polyclonal Antibody
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Catalog No. PIPA5120816
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100 μL
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PIPA5120816 100 μL
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Catalog No. PIPA5120816 Supplier Invitrogen™ Supplier No. PA5120816
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Description

Rabbit Polyclonal Antibody

Positive test controls include: BT-474, 293T. The target is usually found in the following locations: Nucleus, nucleolus. Immunogen sequence: VRVGTQAPRK AGTATSPAGS SPAVAGGTQR PAEDSSSSEE SDSEEEKTGL AVTVGQAKSV GKGLQVKAAS VPVKGSLGQG TAPVLPGKTG PTVTQVKAEK QEDSESSEEE SDSEEAAASP AQVKTSVKKT QAKANPAAAR APSAKGTISA PGKVVTAAAQ AKQRSPSKVK PPVRNPQNST VLARGPASVP SVGKAVATAA QAQTGPEEDS GSSEEESDSE EEAETLAQVK PSGKTHQIRA ALAPAKESPR KGAAPTPPGK TGPSAAQAGK QDDSGSSSEE SDSDGEAPAA VTSAQDQESS.

Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCOF1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.91 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TCOF1
Gene Accession No. Q13428
Gene Alias AA408847; AW209012; MFD1; nucleolar trafficking phosphoprotein; Tcof1; TCS; TCS1; Treacher Collins Franceschetti syndrome 1, homolog; Treacher Collins syndrome protein; Treacher Collins syndrome protein homolog; Treacher Collins-Franceschetti syndrome 1; Treacher Collins-Franceschetti syndrome 1 homolog; treacle; Treacle protein; treacle ribosome biogenesis factor 1
Gene Symbols TCOF1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 659-958 of human TCOF1 (NP_001008657.1).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6949
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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