Invitrogen™ TCP-1 theta Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596289

Catalog No. PIPA596289

Description

Immunogen sequence: DMALHYANKY NIMLVRLNSK WDLRRLCKTV GATALPRLTP PVLEEMGHCD SVYLSEVGDT QVVVFKHEKE DGAISTIVLR GSTDNLMDDI ERAVDDGVNT FKVLTRDKRL VPGGGATEIE LAKQITSYGE TCPGLEQYAI KKFAEAFEAI PRALAENSGV KANEVISKLY AVHQEGNKNV GLDIEAEVPA VKDMLEAGIL DTYLGKYWAI KLATNAAVTV LRVDQIIMAK PAGGPKPPSG KKDWDDDQND; Positive Samples: B cells, LO2, 293T, HeLa, Mouse brain, Mouse liver, Mouse lung, Rat brain; Cellular Location: Cytoplasm, centrosome, cilium basal body, cytoskeleton, microtubule organizing center.

TCP-1 theta is theta subunit of the CCT (chaperonin containing TCP1 complex) chaperonin molecule which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of the newly synthesized proteins. Molecular chaperones assist in the protein folding upon ATP hydrolysis and TCP-1 theta may play a role in the assembly of the BBsome, a complex that is involved in ciliogenesis regulating transport vesicles to the cilia. Further, TCP-1 theta is also involved in the folding of actin and tubulin. The intact CCT complex is composed of eight polypeptides in a double ring structure. CCT is important within cells in the folding of the VHL tumor suppressor protein.

Specifications

• Antigen: TCP-1 theta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCT8
• Gene Alias: AI132397; bdav; bette davis; C21orf112; Cct8; Cctq; CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; chaperonin containing TCP1 subunit 8; chaperonin containing TCP1, subunit 8 (theta); chaperonin subunit 8 (theta); D21S246; fa22h09; KIAA0002; PRED71; renal carcinoma antigen NY-REN-15; T-complex protein 1 subunit theta; TCP-1-theta; Tcpq; wu:fa22h09; zgc:56059
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10694, 12469, 288305
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.25 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P42932, P50990
• Gene Symbols: CCT8
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 248-497 of human CCT8 (NP_0012698371).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG