Invitrogen™ TCR beta Monoclonal Antibody (H57-597)

Armenian Hamster Monoclonal Antibody

Supplier:  Invitrogen™ MA170045

Catalog No. MA170045

Description

MA1-70045 detects alpha/beta TCR in mouse samples. MA1-70045 has been successfully used in flow cytometry, immunoprecipitation, immunohistochemistry (frozen sections), and Western blot procedures. The MA1-70045 immunogen is affinity purified D0 -11.10 TCR. Stable at 4°C. For long term storage, aliquot and freeze unused portions at -20°C in volumes appropriate for single usage. Avoid repeated freeze/thaw cycles.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR beta
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: 0
• Gene Symbols: Tcrb
• Immunogen: Affinity purified D0 -11.10 TCR.
• Quantity: 250 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Clone: H57-597
• Conjugate: Unconjugated
• Gene: Tcrb
• Gene Alias: bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA
• Host Species: Armenian Hamster
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 21577
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov