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Invitrogen™ TCR gamma/delta Monoclonal Antibody (V65), FITC
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA528524
Description
TCR gamma/delta Monoclonal Antibody for Flow
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications
TCR gamma/delta | |
Monoclonal | |
0.1 mg/mL | |
PBS with 4-5mg/mL BSA and 0.02% sodium azide; pH 7.4 | |
0 | |
Trg | |
Rat T Blasts. | |
100 μg | |
Primary | |
Rat | |
Antibody | |
IgG1 |
Flow Cytometry | |
V65 | |
FITC | |
Trg | |
RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@ | |
Mouse | |
Protein G | |
RUO | |
24821 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. | |
Liquid |
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