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  6. Invitrogen™ TCR V beta 11 Monoclonal Antibody (RR3-15), Super Bright™ 436, eBioscience™, Invitrogen™ 

Invitrogen™ TCR V beta 11 Monoclonal Antibody (RR3-15), Super Bright™ 436, eBioscience™, Invitrogen™

Catalog No. 62582780
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62-582-780 25 μg
62-582-782 100 μg
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Catalog No. 62-582-780 Supplier Invitrogen™ Supplier No. 62582780
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Description

Rat Monoclonal Antibody

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCR V beta 11
Applications Flow Cytometry
Classification Monoclonal
Clone RR3-15
Concentration 0.2 mg/mL
Conjugate Super Bright 436
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Alias TCR V beta11; TCRV beta 11; TCRV beta11; Vb11; Vbeta11
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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