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TCR V beta 5b Monoclonal Antibody (W112), FITC, Invitrogen™

Catalog No. PITCR2645
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150 Tests
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PITCR2645 150 Tests
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Catalog No. PITCR2645 Supplier Thermo Scientific Supplier No. TCR2645

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Description

Mouse Monoclonal Antibody

TCR2645 targets TCR V beta 5b in FACS, IHC(F), IP, TCA, and WB applications and shows reactivity with Human samples. The TCR2645 immunogen is human TCR Vb5.3.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCR V beta 5b
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, T-Cell Activation, Western Blot
Classification Monoclonal
Clone W112
Concentration 0.15 mg/mL
Conjugate FITC
Formulation PBS with 0.5% BSA and 0.1% sodium azide
Gene TRB
Gene Accession No. 0
Gene Alias T cell receptor beta locus; TCRB; TRB; TRB@
Gene Symbols TRB
Host Species Mouse
Immunogen Human TCR Vb5.3
Purification Method Protein G
Quantity 150 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6957
Target Species Human
Content And Storage 4° C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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