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Invitrogen™ TCR V delta 2 Monoclonal Antibody (B6)
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Catalog No. PIMA544049
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100 μg
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PIMA544049 100 μg
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Catalog No. PIMA544049 Supplier Invitrogen™ Supplier No. MA544049
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of human TCR Vdelta2, which is expressed on the majority of gamma/delta T cells.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCR V delta 2
Applications Flow Cytometry
Classification Monoclonal
Clone B6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15 mM sodium azide; pH 7.4
Gene TRD
Gene Accession No. 0
Gene Alias PBS with 15mM sodium azide; pH 7.4
Gene Symbols TRD
Host Species Mouse
Immunogen human recombinant TCR Vdelta2.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6964
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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