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Invitrogen™ TCR V gamma 2 Monoclonal Antibody (UC3-10A6), PerCP-eFluor™ 710, eBioscience™
Armenian Hamster Monoclonal Antibody
$427.00
Specifications
Antigen | TCR V gamma 2 |
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Clone | UC3-10A6 |
Concentration | 0.2 mg/mL |
Content And Storage | 4°C, store in dark, DO NOT FREEZE! |
Applications | Flow Cytometry |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-112-9077
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Invitrogen™
46582882 |
100 μg |
Each of 1 for $427.00
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Description
Description: The UC3-10A6 monoclonal antibody reacts with the mouse V gamma 2 (Vg2) delta chain of the gamma delta T cell receptor (TCR). The gamma delta TCR is expressed by a small subset of T cells in the thymus, peripheral lymphoid tissues, intestinal epithelium, and epidermis. The exact specificity, ligand and function of gamma delta TCR-bearing T cells are not yet fully understood. Studies suggest that these cells recognize bacterial ligands and some tumor cells in the context of MHC class I-like gene products and play a role in regulating the immune response during bacterial infection. Applications Reported: This UC3-10A6 antibody has been reported for use in flow cytometric analysis. Applications Tested: This UC3-10A6 antibody has been tested by flow cytometric analysis of C57/Bl splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. PerCP-eFluor® 710 emits at 710 nm and is excited with the blue laser (488 nm); it can be used in place of PerCP-Cyanine5.5. We recommend using a 710/50 bandpass filter, however, the 695/40 bandpass filter is an acceptable alternative. Please make sure that your instrument is capable of detecting this fluoroc...
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.Specifications
TCR V gamma 2 | |
0.2 mg/mL | |
Flow Cytometry | |
PerCP-eFluor 710 | |
Armenian Hamster | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
Primary | |
Affinity chromatography |
UC3-10A6 | |
4°C, store in dark, DO NOT FREEZE! | |
Monoclonal | |
Liquid | |
IgG | |
Mouse | |
TCR V gamma2; TCRV gamma 2; TCRV gamma2; TCRV y2; Vg2; Vgamma2 | |
Antibody |
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