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Invitrogen™ TCR V gamma 9 Monoclonal Antibody (B3), PE
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA544120
Description
This antibody recognizes an extracellular epitope of human TCR Vgamma9, a variant of TCR gamma chain, which is expressed on a gamma/delta T cell subpopulation with cytolytic activity against various tumor cells.
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications
TCR V gamma 9 | |
Monoclonal | |
0.080 mg/mL | |
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4 | |
0 | |
TRG | |
human T cells. | |
100 Tests | |
Primary | |
Human, Monkey | |
Antibody | |
IgG1 |
Flow Cytometry | |
B3 | |
PE | |
TRG | |
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4 | |
Mouse | |
Size-exclusion Chromatography | |
RUO | |
6965 | |
4°C, store in dark, DO NOT FREEZE! | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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