Invitrogen™ TCR V gamma 9 Monoclonal Antibody (B3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA544047

Catalog No. PIMA544047

Description

This antibody recognizes an extracellular epitope of human TCR Vgamma9, a variant of TCR gamma chain, which is expressed on a gamma/delta T cell subpopulation with cytolytic activity against various tumor cells.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Specifications

• Antigen: TCR V gamma 9
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15 mM sodium azide; pH 7.4
• Gene Accession No.: 0
• Gene Symbols: TRG
• Immunogen: human T cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Monkey
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: B3
• Conjugate: Unconjugated
• Gene: TRG
• Gene Alias: PBS with 15mM sodium azide; pH 7.4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 6965
• Content And Storage: 4°C, do not freeze
• Form: Liquid