Invitrogen™ TCTN1 Polyclonal Antibody

Catalog No.	Quantity
PIPA590130	100 μL

Catalog No. PIPA590130 Supplier Invitrogen™ Supplier No. PA590130

Description

Rabbit Polyclonal Antibody

Immunogen sequence: NFTANPPQRV FELVDQINPS IFCIHITNYK PALSFINPEV PDENNFDTLM KTSDGFTLNA ESYVSFTTKL DIPTAAKYEY GVPLQTSDSF LRFPSSLTSS LCTDNNPAAF LVNQAVKCTR KINLEQCEEI EALSMAFYSS PEILRVPDSR KKVPITVQSI VIQSLNKTLT RREDTDVLQP T; Positive Samples: MCF7, HT-29, 293T, NCI-H460; Cellular Location: Cytoplasm, cilium basal body, cytoskeleton.

TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Specifications

• Antigen: TCTN1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 2.27 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: TCTN1
• Gene Accession No.: Q2MV58
• Gene Alias: G730031O11Rik; JBTS13; RGD1566266; TCTN1; TECT1; tectonic family member 1; tectonic-1; UNQ9369/PRO34160
• Gene Symbols: TCTN1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-310 of human TCTN1 (NP_0010760061).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79600
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG