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Invitrogen™ TCTN2 Polyclonal Antibody
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Catalog No. PIPA596985
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PIPA596985 100 μL
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Catalog No. PIPA596985 Supplier Invitrogen™ Supplier No. PA596985
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VKFLSYNSGN EEELSGNPGY QLGKPVRALN INRMNNVTTL HLWQSAGRGL CTSATFKPIL FGENVLSGCL LEVGINENCT QLRENAVERL DSLIQATHVA MRGNSDYADL SDGWLEIIRV DAPDPGADPL ASSVNGMCLD IPAHLSIRIL ISDAGAVEGI TQQEILGVET RFSSVNWQYQ CGLTCEHKAD LLPISASVQF IKIPAQLPHP LTRFQINYTE YDCNRNEVCW PQLLYPWTQY YQGELHSQCV A; Positive Samples: Mouse testis, Mouse brain, Mouse kidney, Mouse lung; Cellular Location: Cytoplasm, Membrane, Single-pass type I membrane protein, cilium basal body, cytoskeleton.

TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13. 5 and E16. 5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCTN2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.89 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TCTN2
Gene Accession No. Q2MV57
Gene Alias 4432405B04Rik; C12orf38; JBTS24; MKS8; Tctn2; TECT2; tectonic 2; tectonic family member 2; tectonic-2
Gene Symbols TCTN2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 420-670 of human TCTN2 (NP_0790852).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 67978
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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