Invitrogen™ TCTN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555473

Catalog No. PIPA555473

Description

Immunogen sequence: QKVNATNFQA LAAEFGGESF TSTFQTQSPP SFYRAGDPIL TYFPKWSVIS LLRQPAGVGA GGLCAESNPA GFLESKSTTC TRFFKNLASS CTLDSALNAA SYYNFTVLKV PRSMTDPQN Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 78%.

TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Specifications

• Antigen: TCTN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TCTN3
• Gene Alias: 4930521E07Rik; AI197391; C10orf61; JBTS18; OFD4; PSEC0041; RGD1305166; RP11-7D5.3; TCTN3; Tect3; tectonic 3; tectonic family member 3; tectonic-3; UNQ1881/PRO4324
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26123
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6NUS6
• Gene Symbols: TCTN3
• Immunogen: Recombinant protein corresponding to Human TCTN3. Recombinant protein control fragment (Product #RP-90154).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG