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Invitrogen™ TCTN3 Polyclonal Antibody
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Catalog No. PIPA555473
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100 μL
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PIPA555473 100 μL
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Catalog No. PIPA555473 Supplier Invitrogen™ Supplier No. PA555473
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QKVNATNFQA LAAEFGGESF TSTFQTQSPP SFYRAGDPIL TYFPKWSVIS LLRQPAGVGA GGLCAESNPA GFLESKSTTC TRFFKNLASS CTLDSALNAA SYYNFTVLKV PRSMTDPQN Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 78%.

TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TCTN3
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TCTN3
Gene Accession No. Q6NUS6
Gene Alias 4930521E07Rik; AI197391; C10orf61; JBTS18; OFD4; PSEC0041; RGD1305166; RP11-7D5.3; TCTN3; Tect3; tectonic 3; tectonic family member 3; tectonic-3; UNQ1881/PRO4324
Gene Symbols TCTN3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TCTN3. Recombinant protein control fragment (Product #RP-90154).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26123
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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