Invitrogen™ TCTN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587479

Catalog No. PIPA587479

Description

Immunogen sequence: QTQSPPSFYR AGDPILTYFP KWSVISLLRQ PAGVGAGGLC AESNPAGFLE SKSTTCTRFF KNLASSCTLD SALNAASYYN FTVLKVPRSM TDPQNMEFQV PVILTSQANA PLLAGNTCQN VVSQVTYEIE TNGTFGIQKV SVSLGQTNLT VEPGASLQQH FILRFRAFQQ STAASLTSPR SGNPGYIVGK PLLALTDDIS YSMTLLQSQG NGSCSVKRHE VQFGVNAISG CKLRLKKADC SHLQQEIYQT LHGRPRPEYV AIFGNADPAQ KGGWTR; Positive Samples: Mouse craniofacial, Mouse lung, Mouse brain; Cellular Location: Membrane, Single-pass type I membrane protein.

TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Specifications

• Antigen: TCTN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TCTN3
• Gene Alias: 4930521E07Rik; AI197391; C10orf61; JBTS18; OFD4; PSEC0041; RGD1305166; RP11-7D5.3; TCTN3; Tect3; tectonic 3; tectonic family member 3; tectonic-3; UNQ1881/PRO4324
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26123, 67590
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.85 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6NUS6, Q8R2Q6
• Gene Symbols: TCTN3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-475 of human TCTN3 (NP_0564464).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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