Invitrogen™ TDE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599729

Catalog No. PIPA599729

Description

Antibody detects endogenous levels of total TDE1.

TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.

Specifications

• Antigen: TDE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Serinc3
• Gene Alias: AA959945; AA960047; Aigp1; AIGP-1; axotomy-induced glyco/Golgi protein 1; Axotomy-induced glycoprotein 1; DIFF33; Membrane protein TMS-1; SBBI99; Serinc3; Serine incorporator 3; TDE; TDE1; Tms1; TMS-1; tumor differentially expressed 1; tumor differentially expressed protein 1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10955
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13530
• Gene Symbols: Serinc3
• Immunogen: A synthesized peptide derived from human SERINC3(Accession Q13530), corresponding to amino acid residues V372-T422.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov