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Invitrogen™ TDG Monoclonal Antibody (GT622)
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Catalog No. PIMA531519
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100 μL
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Catalog No. Quantity
PIMA531519 100 μL
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Catalog No. PIMA531519 Supplier Invitrogen™ Supplier No. MA531519
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Description

Mouse Monoclonal Antibody

Keep as concentrated solution. Predicted reactivity: Human (99%), Mouse (88%), Rat (87%), Bovine (91%). Positive Control: human TDG-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDG
Applications Western Blot
Classification Monoclonal
Clone GT622
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene TDG
Gene Accession No. Q13569
Gene Alias C-JUN leucine zipper interactive protein JZA-3; E130317C12Rik; G/T mismatch-specific thymine DNA glycosylase; hTDG; Jza1; JZA-3; Tdg; thymine DNA glycosylase; thymine-DNA glycosylase
Gene Symbols TDG
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the center region of human TDG. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6996
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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