Invitrogen™ TDO2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5107290

Catalog No. PIPA5107290

Description

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%.

Tryptophan 2,3-dioxygenase (TDO2) is an enzyme encoded by the TDO2 gene, predominantly expressed in the liver and playing a crucial role in tryptophan metabolism through the kynurenine pathway. TDO2 catalyzes the first and rate-limiting step of this pathway, converting tryptophan into N-formylkynurenine. This metabolic process is vital for maintaining systemic tryptophan homeostasis and regulating its availability for protein synthesis and serotonin production. Beyond its metabolic function, TDO2 is involved in modulating immune responses. It contributes to immune tolerance by depleting tryptophan, thereby inhibiting T cell proliferation and promoting regulatory T cell development. Recent research has identified TDO2's role in cancer, particularly in shaping the tumor microenvironment and facilitating immune escape mechanisms through tryptophan catabolism. Its expression is upregulated in several cancers, including gliomas, correlating with tumor severity and patient prognosis. TDO2 and its associated pathways have become therapeutic targets in cancer immunotherapy due to their influence on immune system modulation and metabolism.

Specifications

• Antigen: TDO2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TDO2
• Gene Alias: AA407491; chky; HAMAP-Rule:MF_03020}; TDO; TDO {ECO:0000255; tdo variant1; tdo variant2; TDO2; TO; TO {ECO:0000255; TPH2; TRPO; TRPO {ECO:0000255; tryptamin 2,3-dioxygenase; tryptamin 2,3-dioxygenase {ECO:0000255; Tryptophan 2,3-dioxygenase; tryptophan 2,3-dioxygenase {ECO:0000255; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase; tryptophan oxygenase; tryptophan oxygenase {ECO:0000255; Tryptophan pyrrolase; tryptophan pyrrolase {ECO:0000255; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; tryptophanase; tryptophanase {ECO:0000255
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6999
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P48775
• Gene Symbols: TDO2
• Immunogen: Synthetic peptide directed towards the N terminal region of human TDO2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov