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Invitrogen™ TDO2 Polyclonal Antibody
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Catalog No. PIPA542759
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PIPA542759 100 μL
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Catalog No. PIPA542759 Supplier Invitrogen™ Supplier No. PA542759
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Description

Rabbit Polyclonal Antibody

Peptide sequence: MSGCPFLGNN FGYTFKKLPV EGSEEDKSQT GVNRASKGGL IYGNYLHLEK Sequence homology: Dog: 79%; Human: 100%; Pig: 92%.

Tryptophan 2,3-dioxygenase (TDO2) is an enzyme encoded by the TDO2 gene, predominantly expressed in the liver and playing a crucial role in tryptophan metabolism through the kynurenine pathway. TDO2 catalyzes the first and rate-limiting step of this pathway, converting tryptophan into N-formylkynurenine. This metabolic process is vital for maintaining systemic tryptophan homeostasis and regulating its availability for protein synthesis and serotonin production. Beyond its metabolic function, TDO2 is involved in modulating immune responses. It contributes to immune tolerance by depleting tryptophan, thereby inhibiting T cell proliferation and promoting regulatory T cell development. Recent research has identified TDO2's role in cancer, particularly in shaping the tumor microenvironment and facilitating immune escape mechanisms through tryptophan catabolism. Its expression is upregulated in several cancers, including gliomas, correlating with tumor severity and patient prognosis. TDO2 and its associated pathways have become therapeutic targets in cancer immunotherapy due to their influence on immune system modulation and metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDO2
Applications Immunohistochemistry (Paraffin), Western Blot, Surface Plasmon Resonance
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene TDO2
Gene Accession No. P48775
Gene Alias AA407491; chky; HAMAP-Rule:MF_03020}; TDO; TDO {ECO:0000255; tdo variant1; tdo variant2; TDO2; TO; TO {ECO:0000255; TPH2; TRPO; TRPO {ECO:0000255; tryptamin 2,3-dioxygenase; tryptamin 2,3-dioxygenase {ECO:0000255; Tryptophan 2,3-dioxygenase; tryptophan 2,3-dioxygenase {ECO:0000255; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase; tryptophan oxygenase; tryptophan oxygenase {ECO:0000255; Tryptophan pyrrolase; tryptophan pyrrolase {ECO:0000255; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; tryptophanase; tryptophanase {ECO:0000255
Gene Symbols TDO2
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human TDO2 (aa 1-50).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6999
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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