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Invitrogen™ TDO2 Polyclonal Antibody
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Catalog No. PIPA5116558
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PIPA5116558 100 μL
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Catalog No. PIPA5116558 Supplier Invitrogen™ Supplier No. PA5116558
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Description

Rabbit Polyclonal Antibody

Positive Samples: LO2, U-87MG, Mouse uterus, Rat liver Immunogen sequence: VLQNMRVPYN RRHYRDNF.

Tryptophan 2,3-dioxygenase (TDO2) is an enzyme encoded by the TDO2 gene, predominantly expressed in the liver and playing a crucial role in tryptophan metabolism through the kynurenine pathway. TDO2 catalyzes the first and rate-limiting step of this pathway, converting tryptophan into N-formylkynurenine. This metabolic process is vital for maintaining systemic tryptophan homeostasis and regulating its availability for protein synthesis and serotonin production. Beyond its metabolic function, TDO2 is involved in modulating immune responses. It contributes to immune tolerance by depleting tryptophan, thereby inhibiting T cell proliferation and promoting regulatory T cell development. Recent research has identified TDO2's role in cancer, particularly in shaping the tumor microenvironment and facilitating immune escape mechanisms through tryptophan catabolism. Its expression is upregulated in several cancers, including gliomas, correlating with tumor severity and patient prognosis. TDO2 and its associated pathways have become therapeutic targets in cancer immunotherapy due to their influence on immune system modulation and metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDO2
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 3.08 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TDO2
Gene Accession No. P21643, P48775, P48776
Gene Alias AA407491; chky; HAMAP-Rule:MF_03020}; TDO; TDO {ECO:0000255; tdo variant1; tdo variant2; TDO2; TO; TO {ECO:0000255; TPH2; TRPO; TRPO {ECO:0000255; tryptamin 2,3-dioxygenase; tryptamin 2,3-dioxygenase {ECO:0000255; Tryptophan 2,3-dioxygenase; tryptophan 2,3-dioxygenase {ECO:0000255; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase; tryptophan oxygenase; tryptophan oxygenase {ECO:0000255; Tryptophan pyrrolase; tryptophan pyrrolase {ECO:0000255; tryptophan-2,3-dioxygenase; tryptophan-23-dioxygenase; tryptophanase; tryptophanase {ECO:0000255
Gene Symbols TDO2
Host Species Rabbit
Immunogen Synthetic Peptide.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56720, 64206, 6999
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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