Invitrogen™ TDP-43 Recombinant Rabbit Monoclonal Antibody (4R5L7)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535273

Catalog No. PIMA535273

Description

Immunogen sequence: GNNQGSNMGG GMNFGAFSIN PAMMAAAQAA LQSSWGMMGM LASQQNQSGP SGNNQNQGNM QREPNQAFGS GNNSYSGSNS GAAIGWGSAS NAGSGSGFNG G.

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

Specifications

• Antigen: TDP-43
• Classification: Recombinant Monoclonal
• Concentration: 0.8 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q13148, Q921F2
• Gene Symbols: TARDBP
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human TDP-43/TARDB (Q13148).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ChIP Assay, ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 4R5L7
• Conjugate: Unconjugated
• Gene: TARDBP
• Gene Alias: 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 230908, 23435, 298648
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid