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Invitrogen™ TDP-43 Monoclonal Antibody (GT225)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531504

Catalog No. PIMA531504


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Description

Description

Keep as concentrated solution. Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (83%), Xenopus laevis (91%), Chicken (95%), Bovine (96%). Positive Control: 293T, A431, HeLa, NIH-3T3, Raw264.7, PC-12, Rat2, 293T, TARDBP shRNA-transfected 293T, U87-MG, SK-N-SH, IMR32, SK-N-AS. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3 e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TDP-43
Monoclonal
1 mg/mL
PBS with no preservative
Q13148, Q921F2
TARDBP
Recombinant protein encompassing a sequence within the center region of human TDP43.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG2b
Immunohistochemistry (Paraffin), Western Blot
GT225
Unconjugated
TARDBP
1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Mouse
Protein G
RUO
230908, 23435, 298648
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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