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Invitrogen™ TDP-43 Polyclonal Antibody
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Catalog No. PA116996
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100 μL
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PA116996 100 μL
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Catalog No. PA116996 Supplier Invitrogen™ Supplier No. PA116996
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Description

Rabbit Polyclonal Antibody

Suggested positive control: Hela whole cell extract, antigen standard for TARDBP (transient overexpression lysate).

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TDP-43
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene TARDBP
Gene Accession No. Q13148, Q5ZLN5, Q921F2
Gene Alias 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Gene Symbols TARDBP, tardbp.L
Host Species Rabbit
Immunogen A synthetic peptide to a C-terminal region [within residues 350-414] of the human TARDBP protein.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 230908, 23435, 325052, 380329, 419453
Target Species Human, Mouse, Monkey, Chicken, Frog, Zebrafish
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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