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Invitrogen™ TDP-43 Polyclonal Antibody
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Catalog No. PIPA519712
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100 μg
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Catalog No. Quantity
PIPA519712 100 μg
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Catalog No. PIPA519712 Supplier Invitrogen™ Supplier No. PA519712
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Description

Rabbit Polyclonal Antibody

PA5-19712 targets TARDBP in IF, IHC (F), IP, and WB applications and shows reactivity with Human and mouse samples. The PA5-19712 immunogen is synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human TARDBP. PA5-19712 detects TARDBP which has a predicted molecular weight of approximately 47 kDa.

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
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Specifications

Antigen TDP-43
Applications Western Blot, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.02% sodium azide; pH 7.4
Gene TARDBP
Gene Accession No. Q13148
Gene Alias 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Gene Symbols TARDBP
Host Species Rabbit
Immunogen Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human TARDBP.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23435
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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