TDP1 Monoclonal Antibody (OTI4H1), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-4579	100 μL
50-254-0718	30 μL

Catalog No. 50-167-4579 Supplier OriGene Supplier No. TA503768

Description

Mouse Monoclonal Antibody

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Specifications

• Antigen: TDP1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI4H1
• Concentration: 0.78 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: TDP1
• Gene Accession No.: Q9NUW8
• Gene Alias: tyrosyl-DNA phosphodiesterase 1
• Gene Symbols: TDP1
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human TDP1 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55775
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1