Invitrogen™ TEK Recombinant Rabbit Monoclonal Antibody (116), APC

Catalog No.	Quantity
PIMA546686	100 Tests

Catalog No. PIMA546686 Supplier Invitrogen™ Supplier No. MA546686

Description

Rabbit Recombinant Monoclonal Antibody

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human TIE2 (TEK) (Met1-Lys745) and conjugated with APC under optimum conditions, the unreacted APC was removed. Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

Specifications

• Antigen: TEK
• Applications: Flow Cytometry
• Classification: Recombinant Monoclonal
• Clone: 116
• Concentration: 100 μg/mL
• Conjugate: APC
• Formulation: PBS with 0.5% BSA and 0.09% sodium azide
• Gene: TEK
• Gene Accession No.: Q02763
• Gene Alias: AA517024; Angiopoietin-1 receptor; CD202B; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; endothelium-specific receptor tyrosine kinase 2; endothelium-specific receptor tyrosine kinase Tie-2; hTIE2; Hyk; mTIE2; p140 TEK; protein-tyrosine kinase Tie2; STK1; Tek; TEK receptor tyrosine kinase; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tie2; tie-2; tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2; tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor Tie-2; VMCM; VMCM1
• Gene Symbols: TEK
• Host Species: Rabbit
• Immunogen: Recombinant protein ecoding Human TEK (Met1-Lys745).
• Purification Method: Protein A
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7010
• Target Species: Human
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov