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Invitrogen™ TEM5 Polyclonal Antibody
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Catalog No. PA550672
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100 μL
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PA550672 100 μL
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Catalog No. PA550672 Supplier Invitrogen™ Supplier No. PA550672
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total GPR124 / TEM5 protein.

Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TEM5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene ADGRA2
Gene Accession No. Q91ZV8, Q96PE1
Gene Alias 8430414O08Rik; 9530074E10Rik; Adgra2; Adgra3; Adhesion G protein-coupled receptor A2; adhesion G protein-coupled receptor A3; DKFZp434C211; DKFZp434J0911; FLJ14390; G protein-coupled receptor 124; Gpr124; G-protein coupled receptor 124; KIAA1531; LOC100363275; mKIAA1531; Tem5; Tumor endothelial marker 5
Gene Symbols ADGRA2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to a region derived from internal residues of human G protein-coupled receptor 124.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25960, 78560
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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