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Invitrogen™ TEM5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115317

Catalog No. PIPA5115317


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Description

Description

Antibody detects endogenous levels of total GPR124.

Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TEM5
Polyclonal
Unconjugated
ADGRA2
8430414O08Rik; 9530074E10Rik; Adgra2; Adgra3; Adhesion G protein-coupled receptor A2; adhesion G protein-coupled receptor A3; DKFZp434C211; DKFZp434J0911; FLJ14390; G protein-coupled receptor 124; Gpr124; G-protein coupled receptor 124; KIAA1531; LOC100363275; mKIAA1531; Tem5; Tumor endothelial marker 5
Rabbit
Affinity chromatography
RUO
25960
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide
Q96PE1
ADGRA2
A synthesized peptide derived from human ADGRA2(Accession Q96PE1), corresponding to amino acid residues S1276-C1326.
100 μL
Primary
Human
Antibody
IgG
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