Invitrogen™ TEM7 Monoclonal Antibody (197C193)

Catalog No.	Quantity
PIMA191725	100 μg

Catalog No. PIMA191725 Supplier Invitrogen™ Supplier No. MA191725

Description

Mouse Monoclonal Antibody

MA1-91725 detects TEM7 from human samples.

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

Specifications

• Antigen: TEM7
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 197C193
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene: PLXDC1
• Gene Accession No.: Q8IUK5, Q91ZV7
• Gene Alias: 2410003I07Rik; ADP-ribosylation factor-like 12; AI848450; Arl12; DKFZp686F0937; FLJ36270; FLJ45632; plexin domain containing 1; plexin domain-containing protein 1; PLXDC1; TEM3; TEM7; TEM7 related; tumor endothelial marker 3; Tumor endothelial marker 7; tumor endothelial marker7
• Gene Symbols: PLXDC1
• Host Species: Mouse
• Immunogen: Amino acids 409-425 (LQNNLSPKTKGTPVHLG) of human TEM7 were used to develop this monoclonal antibody.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 303505, 57125, 72324
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1