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Invitrogen™ TEM7 Monoclonal Antibody (197C193 (IM193))

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA141065

Catalog No. 01-676-458


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Description

Description

Suggested positive control: antigen standard for PLXDC1 (transient overexpression lysate), HCT-116.

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TEM7
Monoclonal
1 mg/mL
PBS with 0.05% sodium azide
Q8IUK5, Q91ZV7
PLXDC1
Synthetic petide corresponding to residues 409-425 of human TEM7.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG1
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
197C193 (IM193)
Unconjugated
PLXDC1
2410003I07Rik; ADP-ribosylation factor-like 12; AI848450; Arl12; DKFZp686F0937; FLJ36270; FLJ45632; plexin domain containing 1; plexin domain-containing protein 1; PLXDC1; TEM3; TEM7; TEM7 related; tumor endothelial marker 3; Tumor endothelial marker 7; tumor endothelial marker7
Mouse
Protein G
RUO
303505, 57125, 72324
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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