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Invitrogen™ TEM7 Monoclonal Antibody (197C193 (IM193))
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Catalog No. 01676458
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100 μg
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Catalog No. Quantity
01-676-458 100 μg
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Catalog No. 01-676-458 Supplier Invitrogen™ Supplier No. MA141065
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Description

Mouse Monoclonal Antibody

Suggested positive control: antigen standard for PLXDC1 (transient overexpression lysate), HCT-116. Immunogen sequence: LQNNLSPKTK GTPVHLG.

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TEM7
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 197C193 (IM193)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene PLXDC1
Gene Accession No. Q8IUK5, Q91ZV7
Gene Alias 2410003I07Rik; ADP-ribosylation factor-like 12; AI848450; Arl12; DKFZp686F0937; FLJ36270; FLJ45632; plexin domain containing 1; plexin domain-containing protein 1; PLXDC1; TEM3; TEM7; TEM7 related; tumor endothelial marker 3; Tumor endothelial marker 7; tumor endothelial marker7
Gene Symbols PLXDC1
Host Species Mouse
Immunogen Amino acids 409-425 of human TEM7.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 303505, 57125, 72324
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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