Invitrogen™ TEM7 Monoclonal Antibody (197C193 (IM193))

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA141065

Catalog No. 01-676-458

Description

Suggested positive control: antigen standard for PLXDC1 (transient overexpression lysate), HCT-116.

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

Specifications

• Antigen: TEM7
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q8IUK5, Q91ZV7
• Gene Symbols: PLXDC1
• Immunogen: Synthetic petide corresponding to residues 409-425 of human TEM7.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 197C193 (IM193)
• Conjugate: Unconjugated
• Gene: PLXDC1
• Gene Alias: 2410003I07Rik; ADP-ribosylation factor-like 12; AI848450; Arl12; DKFZp686F0937; FLJ36270; FLJ45632; plexin domain containing 1; plexin domain-containing protein 1; PLXDC1; TEM3; TEM7; TEM7 related; tumor endothelial marker 3; Tumor endothelial marker 7; tumor endothelial marker7
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 303505, 57125, 72324
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov