Invitrogen™ TEM7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113897

Catalog No. PIPA5113897

Description

Immunogen sequence: MDTLPDNRTR VVEDNHSYYV SRLYGPSEPH SRELWVDVAE ANRSQVKIHT For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 93%; Dog: 100%; Guinea Pig: 85%; Horse: 86%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%.

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

Specifications

• Antigen: TEM7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLXDC1
• Gene Alias: 2410003I07Rik; ADP-ribosylation factor-like 12; AI848450; Arl12; DKFZp686F0937; FLJ36270; FLJ45632; plexin domain containing 1; plexin domain-containing protein 1; PLXDC1; TEM3; TEM7; TEM7 related; tumor endothelial marker 3; Tumor endothelial marker 7; tumor endothelial marker7
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57125
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8IUK5
• Gene Symbols: PLXDC1
• Immunogen: Synthetic peptide directed towards the N terminal region of human PLXDC1 (aa 74-123).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov