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Invitrogen™ TEM8 Monoclonal Antibody (200C1339 (SB20))
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Catalog No. 01676457
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100 μg
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Catalog No. Quantity
01-676-457 100 μg
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Catalog No. 01-676-457 Supplier Invitrogen™ Supplier No. MA141059
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Description

Mouse Monoclonal Antibody

Suggested positive control: TEM8 transfected cell lysate. Immunogen sequence: CINFTRVKNN QPAKYPL.

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TEM8
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 200C1339 (SB20)
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene ANTXR1
Gene Accession No. Q9H6X2
Gene Alias 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; anthrax toxin receptor 1; Antrx1; ANTXR1; ATR; FLJ10601; FLJ11298; FLJ21776; GAPO; TEM8; Tem-8; tumor endothelial marker 8
Gene Symbols ANTXR1
Host Species Mouse
Immunogen Synthetic peptide containing amino acids 481-497 of human TEM8.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84168
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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