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Tocris Bioscience™ Temsirolimus
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Catalog No. 526410 Shop All R&D Systems Products
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52-641-0 10mg
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Catalog No. 52-641-0 Supplier Tocris Bioscience™ Supplier No. 5264/10
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Description

mTOR inhibitor; antitumor

Temsirolimus is a mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.

Specifications

Quantity 10 mg
Product Type Temsirolimus
Purity >98%
Molecular Weight (g/mol) 1030.29
Inhibitors Temsirolimus

For Research Use Only

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