Tenascin C Rabbit anti-Human,Mouse,Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA580140

Catalog No. PIPA580140

Description

The synthetic peptide sequence is 27-52aa, NKYVQLNVGGSLYYTTVRALTRHDTM

In most tissues of adults, tenascin C is rarely present at significant levels. However, in developing tissues, or tissues experiencing a fast rate of growth, tenascin C is upregulated. This effect is particularly evident when this extracellular matrix glycoprotein is found in abundance in tissues responding to injury or infection. When muscular pH is increased, tenascin C production also increases. Prostate smooth muscle cells produce extra tenascin C when responding to LPS infection. In fibrosis and stenosis, tenascin C expression levels are markedly increased, and the protein seems to function as a mobilizer of immune cells responding to tissue damage and repair. In COPD, likewise, tenascin C expression is increased and is associated with cells attempting to repair damage within the lung. In short, tenascin C can be expected to be found in adult tissues only when associated with tissue damage and repair efforts.

Specifications

• Antigen: Tenascin C
• Classification: Polyclonal
• Formulation: PBS with 5MG BSA and 0.02% sodium azide, 0.02% thimerosal
• Gene Accession No.: P24821, Q80YX1
• Gene Symbols: Tnc
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Tenascin C.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: TNC
• Gene Alias: Tenascin, TN, Hexabrachion, Tenascin-C, TN-C, Tnc
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116640, 21923, 3371
• Content And Storage: -20°C
• Form: Lyophilized