Invitrogen™ Tensin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563238

Catalog No. PIPA563238

Description

Immunogen sequence: VGSGPHPPDT QQPSPSKAFK PRFPGDQVVN GAGPELSTGP SPGSPTLDID QSIEQLNRLI LELDPTFEPI PTHMNALGSQ ANGSV Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 73%.

The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting a role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane. It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells. Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.

Specifications

• Antigen: Tensin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tns3
• Gene Alias: BC023928; F830010I22Rik; RGD1564174; TEM6; TENS1; TENS3; tensin 3; tensin3; tensin-3; tensin-3-like; tensin-like SH2 domain containing 1; tensin-like SH2 domain-containing 1; tensin-like SH2 domain-containing protein 1; thyroid specific PTB domain protein; TNS3; TPP; TSN3; tumor endothelial marker 6
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64759
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q68CZ2
• Gene Symbols: Tns3
• Immunogen: Recombinant protein corresponding to Human Tensin 3. Recombinant protein control fragment (Product #RP-103240).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov