Invitrogen™ TEP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597264

Catalog No. PIPA597264

Description

Immunogen sequence: TCRESDASMD SDASMDSEPT PHLKTRQRRK IHSGSVTALH VLPELLVTAS KDRDVKLWER PSMQLLGLFR CEGSVSCLEP WLGANSTLQL AVGDVQGNVY FLNWE; Positive Samples: DU145; Cellular Location: Chromosome, Nucleus, telomere.

Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Specifications

• Antigen: TEP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TEP1
• Gene Alias: p230; p240; p80 homolog; p80 telomerase homolog; rTLP1; telomerase associated protein 1; telomerase protein 1; Telomerase protein component 1; telomerase-associated protein 1; Tep1; TLP1; Tp1; TROVE domain family, member 1; TROVE1; VAULT2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7011
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.82 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q99973
• Gene Symbols: TEP1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2523-2627 of human TEP1 (NP_0090412).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov