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TERT Mouse anti-Human, Clone:3H2G9, Abnova™

Catalog No. 89333086 Shop All Abnova Corporation Products
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89-333-086 100 μg
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Catalog No. 89-333-086 Supplier Abnova Corporation Supplier No. MAB16721
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Description

Mouse monoclonal antibody raised against recombinant human TERT.

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq]

Specifications

Antigen TERT
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 3H2G9
Conjugate Unconjugated
Description telomerase reverse transcriptase
Dilution ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
Immunocytochemistry
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.
Formulation In PBS (0.05% sodium azide)
Gene TERT
Gene Alias EST2, TCS1, TP2, TRT, hEST2
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acid 1029-1132 of human TERT from E. coli.
Quantity 100 μg
Gene ID (Entrez) 7015
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Product Type Antibody
Form Liquid
Isotype IgG1
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