Invitrogen™ TET1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120326

Catalog No. PIPA5120326

Description

Positive test controls include: Neuro-2a, Rat heart. The target is usually found in the following locations: Nucleus. Immunogen sequence: TLGSNTETVQ PEVKSETEPH FILKSSDNTK TYSLMPSAPH PVKEASPGFS WSPKTASATP APLKNDATAS CGFSERSSTP HCTMPSGRLS GANAAAADGP G.

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Specifications

• Antigen: TET1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TET1
• Gene Alias: 2510010B09Rik; AA517754; bA119F7.1; BB001228; CXXC finger 6; CXXC zinc finger 6; CXXC6; CXXC-type zinc finger protein 6; D10Ertd17e; KIAA1676; LCX; leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; mKIAA1676; MLL-TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein; ten-eleven translocation 1 gene protein homolog; ten-eleven translocation-1; tet methylcytosine dioxygenase 1; tet oncogene 1; Tet1; TET1 splice variant VP_DE4; TET1 splice variant VP_DE456; TET1-MLL
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 309902, 52463, 80312
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 2.09 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q3URK3, Q8NFU7
• Gene Symbols: TET1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1800-1900 of human TET1 (NP_0851282).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG