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Tocris Bioscience™ Tetrabenazine
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Catalog No. 217550
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21-755-0 50 mg
21-751-0 10 mg
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Catalog No. 21-755-0 Supplier Tocris Bioscience™ Supplier No. 2175/50
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Description

Potent inhibitor of vesicular monoamine transport

Tetrabenazine is an inhibitor of vesicular monoamine transport with a 10-fold selectivity for the VMAT2 transporter over VMAT1 (IC50 values = 0.3 μM and 3.4 μM, respectively). Tetrabenazine blocks D2 receptors and dopamine uptake (IC50 = 0.12 μM) and inhibits serotonin transport by VMAT2 (IC50 = 300 nM). In an animal model of Huntington's disease, Tetrabenazine prevents the decline in motor control and reduces loss of striatal neurons. Tetrabenazine increases cFos expression in the thalamus and hippocampus, reduces brain connectivity and spontaneous locomotion and also causes behavioral depression.

Specifications

Quantity 50 mg
Product Type Tetrabenazine
Purity >98%
Molecular Weight (g/mol) 317.2
Inhibitors Tetrabenazine

For Research Use Only

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