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Tocris Bioscience™ TFB-TBOA
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Catalog No. 253210
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10 mg
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25-321-0 10 mg
25-321 1 mg
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Catalog No. 25-321-0 Supplier Tocris Bioscience™ Supplier No. 2532/10
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Description

High affinity EAAT1 and EAAT2 blocker

TFB-TBOA is a potent and selective glial glutamate transporter EAAT1 and EAAT2 inhibitor (IC50 values are 17, 22 and 300 nM for EAAT2, EAAT1 and EAAT3 respectively). Has no effect on EAAT4 and EAAT5, or a wide range of neuronal receptors and transporters. Attenuates glutamate-stimulated intracellular Na+ elevation in astrocytes in vitro (IC50 = 43 nM). Induces severe convulsions in vivo.

Specifications

Chemical Name or Material (3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-aspartic acid
CAS 480439-73-4
Assay Percent Range >98%
Quantity 10 mg
Solubility Soluble to 100mM in DMSO
Molecular Formula C19H17F3N2O6
Formula Weight Observed MW: 426.35

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